862 research outputs found

    New Boundary Element Method For Analysis Of Surface Subsidence Due To Coal Mining

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    Rock and coal in coal bearing formation belong to layered sedimentary rocks. Their large-scale subsidence may occur because of coal mining. Thus, it is one of research highlights to develop an analytical tool suitable for these layered rocks. This paper presents a new Boundary Element Method(BEM) for analysis of the surface subsidence due to coal mining. The BEM uses the fundamental solution of layered materials,4-8 noded elements to discretize the boundaries, and effective numerical methods to calculate the singular integrals. An example with exact solutions is used to verify the numerical method. Finally, the numerical method is used to analyze in situ surface subsidence due to coal mining. The result shows that the proposed BEM can analyze the surface subsidence due to coal mining with high efficiency and good accuracy. 煤系地層為成層分布的沉積巖,煤層的開采會引起地表大規模的沉陷,發展適應此類介質的分析方法一直是本領域的研究熱點。本文發展了一種新型的邊界元方法來分析煤層開采引起的地表移動。該邊界元方法基于層狀材料基本解,采用4~8變結點單元離散邊界,并采用有效的數值方法計算各類奇異積分。然后,用有解析解的算例驗證建議數值方法。最后,采用新型邊界元方法分析煤層開采引起的地表移動。本文所建議的方法在分析煤層開采引起的地表沉陷時具有較高的計算精度和效率

    The Search for Higher TcT_c in Houston

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    It is a great pleasure to be invited to join the chorus on this auspicious occasion to celebrate Professor K. Alex Mueller's 90th birthday by Professors Annette Bussman-Holder, Hugo Keller, and Antonio Bianconi. As a student in high temperature superconductivity, I am forever grateful to Professor Alex Mueller and Dr. Georg Bednorz "for their important breakthrough in the discovery of superconductivity in the ceramic materials" in 1986 as described in the citation of their 1987 Nobel Prize in Physics. It is this breakthrough discovery that has ushered in the explosion of research activities in high temperature superconductivity (HTS) and has provided immense excitement in HTS science and technology in the ensuing decades till now. Alex has not been resting on his laurels and has continued to search for the origin of the unusual high temperature superconductivity in cuprates.Comment: Dedicated to Alex Mueller, whose "important breakthrough in the discovery of superconductivity in ceramic materials" in 1986 has changed the world of superconductivit

    Low-temperature microstructural studies on superconducting CaFe2As2.

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    Undoped CaFe2As2 (Ca122) can be stabilized in two slightly different non-superconducting tetragonal phases, PI and PII, through thermal treatments. Upon proper annealing, superconductivity with a Tc up to 25 K emerges in the samples with an admixture of PI and PII phases. Systematic low-temperature X-ray diffraction studies were conducted on undoped Ca122 samples annealed at 350 °C over different time periods. In addition to the diffraction peaks associated with the single-phase aggregation of PI and PII, a broad intermediate peak that shifts with annealing time was observed in the superconducting samples only. Our simulation of phase distribution suggests that the extra peak is associated with the admixture of PI and PII on the nanometer scale. High-resolution transmission electron microscopy confirms the existence of these nano-scale phase admixtures in the superconducting samples. These experimental results and simulation analyses lend further support for our conclusion that interfacial inducement is the most reasonable explanation for the emergence of superconductivity in undoped Ca122 single crystals

    SUMO-2 promotes mRNA translation by enhancing interaction between eIF4E and eIF4G

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    Small ubiquitin-like modifier (SUMO) proteins regulate many important eukaryotic cellular processes through reversible covalent conjugation to target proteins. In addition to its many well-known biological consequences, like subcellular translocation of protein, subnuclear structure formation, and modulation of transcriptional activity, we show here that SUMO-2 also plays a role in mRNA translation. SUMO-2 promoted formation of the active eukaryotic initiation factor 4F (eIF4F) complex by enhancing interaction between Eukaryotic Initiation Factor 4E (eIF4E) and Eukaryotic Initiation Factor 4G (eIF4G), and induced translation of a subset of proteins, such as cyclinD1 and c-myc, which essential for cell proliferation and apoptosis. As expected, overexpression of SUMO-2 can partially cancel out the disrupting effect of 4EGI-1, a small molecule inhibitor of eIF4E/eIF4G interaction, on formation of the eIF4F complex, translation of the cap-dependent protein, cell proliferation and apoptosis. On the other hand, SUMO-2 knockdown via shRNA partially impaired cap-dependent translation and cell proliferation and promoted apoptosis. These results collectively suggest that SUMO-2 conjugation plays a crucial regulatory role in protein synthesis. Thus, this report might contribute to the basic understanding of mammalian protein translation and sheds some new light on the role of SUMO in this process. © 2014 Chen et al

    Changing planar thin film growth into self-assembled island formation by adjusting experimental conditions

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    Illustrated in this paper are two examples of altering planar growth into self-assembled island formation by adapting experimental conditions. Partial oxidation, undersaturated solution and high temperature change Frank-Van der Merwe (FM) growth of Al0.3Ga0.7As in liquid phase epitaxy (LPE) into isolated island deposition. Low growth speed, high temperature and in situ annealing in molecular beam epitaxy (MBE) cause the origination of InAs/GaAs quantum dots (QDs) to happen while the film is still below critical thickness in Stranski-Krastanow (SK) mode. Sample morphologies are characterized by scanning electron microscopy (SEM) or atomic force microscopy (AFM). It is suggested that such achievements are of value not only to fundamental researches but also to spheres of device applications as well. (c) 2004 Elsevier B.V. All rights reserved

    Gremlin-1 Induces BMP-Independent Tumor Cell Proliferation, Migration, and Invasion

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    Gremlin-1, a bone morphogenetic protein (BMP) antagonist, is overexpressed in various cancerous tissues but its role in carcinogenesis has not been established. Here, we report that gremlin-1 binds various cancer cell lines and this interaction is inhibited by our newly developed gremlin-1 antibody, GRE1. Gremlin-1 binding to cancer cells was unaffected by the presence of BMP-2, BMP-4, and BMP-7. In addition, the binding was independent of vascular endothelial growth factor receptor-2 (VEGFR2) expression on the cell surface. Addition of gremlin-1 to A549 cells induced a fibroblast-like morphology and decreased E-cadherin expression. In a scratch wound healing assay, A549 cells incubated with gremlin-1 or transfected with gremlin-1 showed increased migration, which was inhibited in the presence of the GRE1 antibody. Gremlin-1 transfected A549 cells also exhibited increased invasiveness as well as an increased growth rate. These effects were also inhibited by the addition of the GRE1 antibody. In conclusion, this study demonstrates that gremlin-1 directly interacts with cancer cells in a BMP- and VEGFR2-independent manner and can induce cell migration, invasion, and proliferation
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